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Set in the future, the plot centers on Zouichi Kanoe and his motorcycle's built-in AI partner, Fuyu Kanoe, whose luminous form is an integral component of the bike's OS. As agents of Toha Heavy Industries, their task is to rescue individuals with the ability to resist and modify the N5S epidemic, a contagious illness that is converting the populace into "Drones" - monstrous and undead beings - and disseminating swiftly throughout the planet.