In a bid to improve their soccer standings, the Japanese Football Association contracts the mysterious coach Jinpachi Ego to assist them in winning the World Cup. Jinpachi introduces the controversial Blue Lock program, which rounds up 300 talented high school strikers and pits them against each other. The ultimate prize is the coveted position of the national team's striker, but only the last player standing can claim it - failure means never joining the team.
Yoichi Isagi, a striker who failed at securing a win for his high school team in the national tournament, is called to take part in the high-risk Blue Lock project. Puzzled by the impact of his selflessness on his ability to score, Yoichi questions his team play strategy. However, with Blue Lock serving as his ultimate chance to chase his dreams and lead Japan to World Cup greatness as the world's best striker, he focuses on perfecting his skills to win the grueling competition.