Two millennia have elapsed since the Dark Knight Sparda led a rebellion, transforming from demon to champion of good in the process and sealing off the gateway to his former realm. With humanity protected, Sparda's son Dante pursues demons, vowing to banish any threat to their peace. His latest mission takes him on a daring pursuit of a girl named Alice, and what fate awaits him at her hideout is yet to be unveiled. Meanwhile, an unknown figure identical to Dante roams the vicinity.
Sparda's other son, Vergil, is vastly different from Dante. However, his motive remains unknown. The journey of these two destiny-bound siblings continues to unfold.