Shinonome Keisuke, a once prodigious surgeon, roams the world as a ghost with the ability to communicate solely with Kotone Tasuku. Tasuku is the only one who can see and converse with him. When Takeuchi Mai's little brother sustains severe injuries due to a mishap, Shinonome and Tasuku must collaborate to form an atypical and remarkable emergency medical team to save him. This partnership creates the most extraordinary medical duo the nation has ever seen. The book also includes a one-shot story entitled "Little Big Doctor" (pilot).