Hitori Bocchi is plagued by severe social anxiety, causing her to struggle with conversation and turn to drastic measures to avoid social situations. She experiences cramping in her legs from overexertion, becomes overly confident when left to her own devices, and even vomits when under extreme stress. As she begins her journey in middle school, her sole friend, Yawara Kai, is attending a different school, leaving Bocchi to navigate new surroundings and make new friends in order to regain Kai's friendship.