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Ancient sorcerers once crafted a deadly medical weapon known as Byouma, capable of disguising murder as a natural illness. Despite the death of its creators, these weapons still roam the earth, infecting and killing unsuspecting victims. To confront this danger, Narutaki Soutarou and Izumo Momo have trained as Shadow Doctors, equipped with rare anti-Byouma technology and unconventional medical techniques. But can their unique skills and teamwork eradicate every last Byouma threat?