The world relies on heroes, and Kunugigaoka Magical Academy is renowned for producing the best. Consequently, the school expects their students to surpass high standards. However, End-Class - dubbed "E" - frequently misses the mark, and as a result, they experience contempt, ridicule, and discrimination from their peers.
Yet, when the Demon King presents himself, the underachievers must not give up yet. They unveil their unique and quirky talents, previously considered as hindrances, as a representation of their individuality. The enemy of humanity then declares himself their new homeroom teacher. Koro-sensei, an invincible instructor, and Tadaomi Karasuma, Royal Knights' captain, undertake the responsibility of guiding Class-E to become heroes and eventually eliminate the Demon King.
As they confront foes like the Five Virtuosos, the Pope, and several monsters, Class-E must strive towards their ultimate objective: to conquer their teacher, the Big Bad.