The first volume of Manhole depicts the surprising intersection of two Japanese detectives, a nude man on an urban thoroughfare, and a worm from Botswana. In their bid to solve a string of enigmatic and gruesome homicides, Ken Mizoguchi and Nao Inoue stumble upon a harmful biological substance that looms as a danger of large-scale epidemic. Their inquiries lead them to an improbable suspect, a self-professed photographer, as the infections continue to proliferate. This series offers a captivating blend of detective fiction and biological terror.