Maniac Road recounts the tale of a dilapidated electronics store situated in the secluded alleys of Akihabara, Japan, owned by three sisters struggling to keep it afloat. To revitalize the store's fortunes, the sisters enlist the help of Takezou, a savvy individual. Through his innovative thinking, Takezou remodels the store into the ideal hub for otaku enthusiasts. Consequently, business skyrockets, and the sisters embark on an exciting journey, meeting diverse and peculiar individuals immersed in Japan's burgeoning manga/anime culture.