Rintarou harbors strong prejudices against women and despises his father's infidelity with their female neighbor. He adamantly refuses to follow his father's footsteps and frequently utilizes derogatory gender-specific terms when thinking about his female peers, with the exception of Azusa Yatsugi, who is the most unassuming girl in his class. However, a mosquito-transmitted illness is rapidly infecting women in his locality, manifesting as high fever and intense sexual assertiveness. Can Rintarou and Azusa survive the outbreak unscathed?