Centuries ago, a woman's romance with a mysterious being resulted in the creation of the Saishi. This deadly combination of human and beast possessed venomous abilities, making them formidable weapons during times of war. However, during times of peace, they were shunned and dreaded for their very existence.
Gen Tsukinosuke, a samurai without a master, is among the few remaining Saishis. Armed with the legendary "Fangs of God," he pursues his quest to locate his sister. He fulfills his desires with women seeking death, using his lethal powers to end their suffering. As the Edo era nears its end, Tsukinosuke faces the burden of his undeniable fate, consumed by the cruel destiny of his past.
