The plot of Isle of Dogs revolves around a 12-year-old boy named Atari Kobayashi, who is under the guardianship of the corrupt Mayor Kobayashi. One day, an Executive Decree is issued, resulting in all the pet dogs of Megasaki City being banished to a gigantic dumpsite known as Trash Island. In an attempt to find his loyal dog protector Spots, Atari sets out on a solo mission in a miniature flying machine called the Junior Turbo Prop, crossing the river in the process. Accompanied by a group of newfound stray canine companions, Atari embarks on an extraordinary quest that will determine the prospects and destiny of the entire region.