The "Holmes Agency" goes by the nickname of the "Big-Eating" Detective Office, and their newest leader, Seiya Takano, is infamous for his insatiable appetite. Seiya supervises Ryousuke Noda and Kyouko Izumi, who also possess hearty appetites, as they investigate various crimes, including murder, robbery, and kidnapping. What sets them apart from other detectives is their unique method of solving cases: they rely on their appetite to guide them. They feast at crime scenes, on the run, and even on dog food, using their love of food to uncover hidden clues. Their unconventional approach has led to miraculous breakthroughs, much to the astonishment of witnesses. Through their passion for gourmet cuisine and deep knowledge of food, the "Big-Eating" detectives tackle cases that blend the worlds of delicious food and fascinating mysteries.