Yuu, the young female lead in Creamy Mami, gains supernatural powers for a year after stumbling upon a spaceship. Two cat companions, Poji and Nega, guide her on her journey. Yuu embraces her alter ego as pop star Creamy Mami and faces various challenges including acting, singing, working at her family's creperie, fending off evil extraterrestrial foes and foes, attending school, and trying to win over her crush Toshio.