The narrative of Medicine revolves around Naoki and his female cousin Yayoi, who are staying at Naoki's house with their families. While the adults mingle downstairs, Naoki pretends to have asthma and lays in his room. In actuality, he is feeling down and has caught a cold after being rejected by a girl he had feelings for.
However, Yayoi notices his ploy and barges into his room to ask about his troubles. Though Naoki is initially hesitant, he eventually confides in her. Luckily, Yayoi extends her sympathy and gives him a "good luck charm" to help him feel better...
