On her birthday, Little yearns for a mundane existence, rejecting her actual identity as a breathtaking 114-year-old vampire who commutes every day to Rose Academy in Usuyami Town. Her brother, Radou, keeps a watchful eye on her as she is assisted by her werewolf attendant, Inukai, and magical friend, Shinji. However, her academic goals are under threat from a malevolent ghost.