In 2005, private investigators with exceptional skills were highly sought after due to the police's struggle in handling intricate and vital cases. Seiji Hayami and Hisashi Hanyuu were among the chosen individuals to investigate peculiar reports of monstrous creatures. As they delve deeper into their pursuit, they find themselves in a fierce battle against the Panther Claw terrorist group, whose obsession with the goddess Zora and their ferocious leader Sister Jill pose a significant threat. Despite the unfavorable odds, Cutie Honey, a time-traveling android from the 70s, teams up with them to bring down Panther Claw. Cutie Honey now lives with Seiko, assuming the identity of Hisashi.