Mazinger Angels tells the humorous adventures of four female robot pilots who derive inspiration from the Mazinger series. The story pays tribute to Charlie's Angels, the famous television show from the late 70s and early 80s.
Aphrodite A, Diana A, Minerva X, and Venus A from Great Mazinger serve as the prototypes for the robots. The pilots are familiar faces from Go Nagai's universe such as Sayaka Yumi and Jun Hono from Mazinger Z and Great Mazinger. Hikaru Makiba and Maria Fleed from Grendizer also make an appearance.
The manga's visual representation emphasizes the physical attractiveness of both the characters and their machines, similar to how women are portrayed in Aika.